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Year : 2008  |  Volume : 5  |  Issue : 3  |  Page : 70-77

Hyperthyroidism-related muscular disease


Department of Endocrinology and Diabetes, Amrita Institute of Medical Sciences, Elamakkara, Cochin 682026, India

Correspondence Address:
A G Unnikrishnan
Department of Endocrinology and Diabetes, Amrita Institute of Medical Sciences, Elamakkara, Cochin 682026
India
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Source of Support: None, Conflict of Interest: None


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Muscular disorders can occur in hyperthyroidism. These include thyrotoxic myopathies and thyrotoxic periodic paralysis. Thyrotoxic myopathies are the commonest manifestation, and usually affect the proximal muscles. Occasionally, these myopathies may be more localized in nature, and several examples of discrete involvement, for instance bulbar paralyses and diaphragmatic weakness have been reported in medical literature. Thyrotoxic periodic paralysis is an acute severe form of muscle weakness and declining potassium levels that is associated with thyrotoxicosis. In addition, Graves 'Ophthalmopathy, which involves the extra-ocular muscles, is associated with, but not causally linked to thyroid hormone excess. Finally, the prevalence of myasthenia gravis is higher in subjects with thyrotoxicosis. This article will focus on the spectrum of muscular involvement seen in subjects with thyrotoxicosis.


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