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ORIGINAL ARTICLE
Year : 2011  |  Volume : 8  |  Issue : 3  |  Page : 7-11

Prevalence of thyroid autoimmunity in type 1 diabetes mellitus: Thyroid autoimmunity in type 1 diabetes


Department of Endocrinology and Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati, India

Correspondence Address:
A Sachan
Department of Endocrinology and Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati
India
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Source of Support: None, Conflict of Interest: None


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Objective - To determine the prevalence of thyroid autoimmunity in patients with type 1 diabetes mellitus.n Methods - Data were analyzed from 22 patients (7 males, 15 females) with type 1 diabetes aged 7 to 29 years who were under follow up at SVIMS, Tirupati. Antibodies to thyroid peroxidase (anti-TPO) were measured in all patients. The mean age was 14.2 years (min - max 7-29 years), and mean duration of diabetes was 5.3 years (min - max 0.1-22 years). Results - Nine (41 %) patients, had elevated (>18A U/ml) anti-TPO levels. While 8 of 15 girls (53%) were positive for anti TPO antibodies only 1 out of 7 boys (14.2%) were likewise positive. Eight of the nine (88.9%) patients who were positive for TPO antibodies also had a goiter while only 2 of the 13 (15.4%) patients lacking TPO antibodies had a goiter (p<0.001). Using TPO as the serological gold standard for the diagnosis of thyroid autoimmunity, the sensitivity and specificity of clinical goiter presence in identifying underlying thyroid autoimmunity was 88.9% and 84.6% respectively. Of the 9 patients who were positive for anti TPO antibodies, 7 (78%) had biochemical evidence of hypothyroidism. All of them were girls. However only two had frank hypothyroidism (both had TSH > 50 IU/ml). Conclusions - Thyroid autoimmunity and consequent hypothyroidism is common in type 1 diabetes thus emphasizing the importance of screening.


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