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ORIGINAL ARTICLE
Year : 2013  |  Volume : 10  |  Issue : 3  |  Page : 100-103

Evaluation of upper reference limit of TSH in adults: Review of biological upper reference limit for TSH on a "chemiluminescence based" analysis technique


1 Department of Biochemistry, St John's Medical College and Hospital, Koramangala, Bangalore, India
2 Department of Endocrinology, St John's Medical College and Hospital, Koramangala, Bangalore, India
3 Scientific Affairs, Beckman Coulter, Inc., Brea, USA

Correspondence Address:
Sultana Furruqh
Department of Biochemistry, St. John's Medical College and Hospital, Sarjapur Road, Koramangala, Bangalore
India
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Source of Support: Statistical work of the final data, reagents & consumables provided by Beckman Coulter India Private Limited. Technical expertise and laboratory work provided by the Departments of Clinical Biochemistry & Endocrinology St. Johnís Medical College Hospital, Conflict of Interest: None


DOI: 10.4103/0973-0354.116137

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Background: There was an identified need to review the use of the manufacturer provided upper reference limit (URL) of the thyroid stimulating hormone (TSH) assay for the Indian population. URL's provided by manufacturers are usually based on western populations. This study triggered from our clinical feedback, identified that there is indeed difference for the URL for the Indian population compared to what the manufacturer has provided for the TSH assay. Materials and Method: Prospective study with volunteers from St. John's Medial College Hospital general health check who were pre-screened and selected based on inclusion/exclusion criteria decided for the purpose. We utilised the Access ® range of Chemiluminescence based Immuno assay system from Beckman Coulter Inc., Brea. CA, USA for this study. As indicated in the "background", we investigated URL of the TSH assay. Results and Conclusion: Results strongly favored the reduction of the URL to be more suitable for the population covered in this study.


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