Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Home Print this page Email this page
Users Online: 510


MINI REVIEW
Year : 2013  |  Volume : 10  |  Issue : 4  |  Page : 3-4

TSH and longevity


Department of Endocrinology & Metabolism; IPGME&R/SSKM Hospital, Kolkata, India

Correspondence Address:
Subhankar Chowdhury
Professor & Head, Department of Endocrinology & Metabolism, Ronald Ross Building; 4th Floor, IPGME&R/SSKM Hospital, 244, A. J. C Bose Road, Kolkata - 20
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-0354.106801

Rights and Permissions

The process of normal aging affects the hypothalamic-pituitary-thyroid axis in a number of ways, resetting of the set point being the most important of them. Contrary to the earlier belief, longevity has been reported to be associated with high serum TSH. Most recent studies have demonstrated an age dependent decline in serum free T3 levels, whereas FT4 levels remains relatively unchanged and TSH & rT3 levels increase with age. Two recent meta-analyses have shown increased risk of adverse cardiovascular outcomes in patients younger than 65 years of age, but not in those more than 65 year old. There is a good number of evidence documenting increased mortality in elderly individual with sub- clinical hyperthyroidism, which should be kept in mind while treating mildly elevated TSH in these patients. It is also important to remember that thyroid functions in the elderly closely mimics that found in sick euthyroid syndrome.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2406    
    Printed98    
    Emailed0    
    PDF Downloaded1138    
    Comments [Add]    

Recommend this journal