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ORIGINAL ARTICLE
Year : 2015  |  Volume : 12  |  Issue : 3  |  Page : 87-92

Low serum free and total tri-iodothyronine hormones as possible prognostic factors in liver cirrhotic patients due to chronic hepatitis C


Department of Internal Medicine, Gastroenteology and Hepatology Unit, Tanta University Hospital, Tanta, Egypt

Correspondence Address:
Mohamed Abd El-Raouf Tawfik
Department of Internal Medicine, Gastroenteology and Hepatology Unit, Tanta University Hospital, Tanta
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-0354.157935

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Background and Aim: Liver and thyroid hormones are powerfully correlated so thyroid hormone abnormalities are seen in patients of liver diseases We evaluated serum thyroid hormone levels in chronic hepatitis C cirrhotic patients with and without hepatic encephalopathy. Patients and Methods: Our study was carried out on one hundred patients with chronic hepatitis C (CHC) related liver cirrhosis (66 male and 34 female). they were divided to three groups: Group I which included 40 patients proved to have liver cirrhosis due to CHC with hepatic encephalopathy (26 male and 14 female), Group II which included 60 patients proved to have liver cirrhosis due to CHC without hepatic encephalopathy (40 males and 20 females), Group III which included 20 healthy subjects was taken as control group (12 males and 8 females). Free tri-iodothyroinine (FT3), free thyroxine (FT4), total T3, total T4 and thyrotropine stimulating hormone (TSH) were tested. Results: (Group I) and (Group II) showed a significant decrease in T3 and FT3 levels compared to controls (Group III) whereas there was no difference in serum T4, TSH and FT4 levels. all (Group I) had significantly reduced levels of T3 and FT3 compared to (Group II), whereas there was no difference in T4, FT4 and TSH levels. Conclusion: Patients with chronic CHC have significant lower serum FT3 and T3. Patients with hepatic encephalopathy were found to have exceedingly low serum T3 and FT3 levels. Depressed serum T3 and FT3 levels, together with a prolonged prothrombin time and hypo-albuminemia, therefore appear to be characteristic of decompensated cirrhotic patients prone to develop hepatic encephalopathy.


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