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REVIEW ARTICLE
Year : 2016  |  Volume : 13  |  Issue : 2  |  Page : 52-56

Core needle biopsy: An additional diagnostic armamentarium


Department of Endocrinology, Army Hospital Research and Referral, New Delhi, India

Correspondence Address:
Dr. Shrikant Somani
Department of Endocrinology, Army Hospital Research and Referral, Dhaula Kuan, Delhi Cantt., New Delhi - 110 010
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-0354.183280

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Fine needle aspiration cytology (FNAC) is considered to be most effective and accurate diagnostic test to differentiate benign from malignant thyroid nodules and most guidelines recommend FNAC as the initial test. However, significant percentage of FNAC results are inconclusive owing to nodule characteristic, operator limitations, or limitations of the procedure itself. Core needle biopsy (CNB) in the evaluation of thyroid nodules have been performed since many decades; however, due to large bore needle, complication rates, and previous reports of inaccuracies, presently CNB has not been included by most guidelines in the diagnostic algorithm of thyroid nodules. Multiple recent studies have shown much higher rates of sensitivity, specificity, and accuracy using CNB in differentiating benign from malignant lesions, particularly when initial FNA is indeterminate, nondiagnostic or if there are discordant results between radiologic and cytologic tests or in nodules with macrocalcifications or fibrosis.


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