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CASE REPORT
Year : 2019  |  Volume : 16  |  Issue : 1  |  Page : 36-38

An uncommon presentation of a common disorder: Van Wyk–Grumbach syndrome


1 Department of Endocrinology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
2 Department of General Medicine, Alluri Sitaramaraju Academy of Medical Sciences, Eluru, Andhra Pradesh, India
3 Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India

Correspondence Address:
Dr. Beatrice Anne
Department of Endocrinology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad - 500 082, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/trp.trp_3_19

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Van Wyk–Grumbach syndrome (VWGS) is characterized by juvenile hypothyroidism, delayed bone age, and isosexual precocious puberty. We report the case of a 7-year-old girl who presented with premature menarche, short stature, and isosexual precocity. She had delayed bone age and multicystic ovaries. High circulating levels of thyroid-stimulating hormone (TSH) with prepubertal luteinizing hormone confirmed the diagnosis of VWGS. High circulating levels of TSH acting directly on follicle-stimulating hormone receptors could be the mediators of precocity. VWGS syndrome is quite rare and needs to be suspected for prompt treatment and resolution and avoidance of unnecessary surgery.


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