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ORIGINAL ARTICLE
Year : 2019  |  Volume : 16  |  Issue : 1  |  Page : 3-5

Thyroid dysfunction in patients with Type-2 diabetes mellitus in Kerala: A case–control study


1 Family Physician, VPS Lakeshore Hospital, Palakkad, Kerala, India
2 Family Physician, PHC Perumatty, Palakkad, Kerala, India
3 Physician, Valluvanad Hospital, Ottapalam, Kerala, India

Correspondence Address:
Dr. Muhammed Jasim Abdul Jalal
Department of Family Medicine, VPS Lakeshore Hospital, NH 47 Bypass, Nettoor P.O., Maradu, Kochi - 682 040, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/trp.trp_47_18

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Aim: The aim of this study is to establish the relationship between type 2 diabetes mellitus (Type 2 DM) and thyroid dysfunction. Objective: The objective of this study is to study: (1) The prevalence of thyroid dysfunction in Type-2 DM. (2) The spectrum of thyroid dysfunction. Study Design: This was a case-control study. Study Setting: This study was conducted in Family Medicine outpatient clinics in Thrissur, Kerala. Subjects and Methods: A total of 50 cases (diagnosed case of Type 2 DM) and 50 healthy controls were taken into consideration randomly. Thyroid function tests were conducted using the chemiluminescence assay. Then, it was analyzed statistically after tabulation. Statistical Analysis: Statistical analysis was performed using the Chi-square test for categorical variables. Student's t-test was used for finding significance between the means. A “P < 0.05” was considered statistically significant. Results: Thyroid dysfunction was found to be more in type 2 DM (16%) than in healthy controls (4%) which were significant. Among those diabetic patients with thyroid dysfunction, 6 (75%) out of 8 were females. The mean body mass index was high in diabetic patients with thyroid dysfunction. The hemoglobin A1c levels in patients who had thyroid dysfunction were high. Those with thyroid dysfunction had a mean total cholesterol level higher than euthyroid diabetics and controls. Goiter was found to be present in 4% of cases of Type 2 DM. Conclusion: Type 2 DM and thyroid diseases have a significant association. Subclinical hypothyroidism and overt hypothyroidism were the most common thyroid abnormality in Type 2 DM. Thyroid dysfunction was associated with worsening dyslipidemia in Type 2 DM.


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