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ORIGINAL ARTICLE
Year : 2019  |  Volume : 16  |  Issue : 1  |  Page : 6-11

Cryoablation of goiter irrespective of thyroid profile


1 Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3 Department of Endocrinology, National Institute of Diabetes and Endocrinology, Cairo, Egypt

Correspondence Address:
Dr. Nesma Ali Ibrahim
Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/trp.trp_54_18

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Introduction: Thyroid nodules (TNs) are extremely common and most of them are benign in nature. Cryoablation is used in a variety of clinical applications, and has been applied in focal treatment as a substitute or an adjunct to surgery and other nonoperative modalities. Objectives: The objective is to evaluate the effect of cryoablation on the size and function of TN. Subjects and Methods: This was an interventional therapeutic study, conducted at endocrinology clinic, Ain Shams University Hospitals. Our study sample included 80 participants, aged between 20 and 60 years, having TN diagnosed by ultrasound (US). The participants were divided into two groups: Group 1 (control group) included 40 participants who were not subjected to cryoablation and Group 2 (cases) included 40 participants upon which cryoablation was done. Neck US was done for participants and they were sampled for their thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free tetraiodothyronine (FT4) levels at start and after 3 and 6 months. Results: There was a high statistically significant difference between Group 1 and Group 2 regarding nodule size after 6 months (0.87 ± 0.25 cm vs. 0.67 ± 0.21 cm, respectively, P < 0.001), in spite of non-significant difference between both groups at the start of study (0.79 ± 0.29 cm vs. 0.83 ± 0.29 cm, respectively, P = 0.619). The median percentage of change in nodule size from 0 to month 6 in control group was +12.50% (IQR: 0%–22.5%), while in cases was −25.0% (IQR: −50%–−4.17%), P < 0.001. Regarding thyroid function tests, there was no statistically significant difference between both groups all through our study. Conclusions: Cryoablation causes nodule size reduction, while it does not affect thyroid function tests.


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