Thyroid Research and Practice

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 13  |  Issue : 3  |  Page : 106--109

Trimester specific ranges for thyroid hormones in normal pregnancy


Jidnyasa Mankar1, Anagha Sahasrabuddhe1, Shailesh Pitale2 
1 Department of Physiology, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India
2 Pitale Diabetes and Hormone Center, Nagpur, Maharashtra, India

Correspondence Address:
Anagha Sahasrabuddhe
5 Charushree Apartments, Khare Town, Dharampeth, Nagpur - 440 010, Maharashtra
India

Maternal and fetal thyroid profiles differ throughout gestation. Due to many physiological changes during pregnancy, interpretation of thyroid function tests needs trimester specific reference intervals. American Thyroid Association strongly recommends to refer to population defined trimester-specific reference ranges with optimal iodine intake Though some studies have reported this reference range in South and a few in North, there has been no data from Central India yet. Aims and Objectives: To establish normative range of TSH in each trimester of pregnancy, To establish normative range of f T3 and f T4 in each trimester of pregnancy and to know the prevalence of subclinical hypothyroidism in normal pregnancies. Materials and Methods: in all 177 normal singleton pregnant women were screened and out of them 150 enrolled in the study(50 in each trimester). Their TSH, fT3, fT4 and urinary iodine was estimated. Observations and Results: The reference range of thyroid hormones for 1st trimester found in the present study are as follows: TSH: 0.24-4.17 (uIU/ml), fT3: 0.29-3 .1 (ng/100 ml), fT4: 01-2.2 (ng/100 ml). For 2 nd trimester: the reference range for TSH , fT3 and fT4 are 0.78-5.67 (uIU/ml) , 0.27-3.34(ng/100 ml) ,and 0.45-2.24 (ng/100 ml) respectively. For 3 rd trimester, the reference range for TSH , fT3 and fT4 are 0.47-5.78 (uIU/ml), 0.24-3.61(ng/100 ml) and 0.47-5.1 (ng/100 ml). Prevalence of subclinical hypothyroidism was found to be 4% in first and second trimesters and 8% in third trimester. No case was seen with clinical hypothyroidism. Conclusion: This study states the range of thyroid hormones in all 3 trimesters of pregnancy. The prevalence of subclinical hypothyroidism was found out to be 4% in first and second trimesters each and 8% in third trimester.


How to cite this article:
Mankar J, Sahasrabuddhe A, Pitale S. Trimester specific ranges for thyroid hormones in normal pregnancy.Thyroid Res Pract 2016;13:106-109


How to cite this URL:
Mankar J, Sahasrabuddhe A, Pitale S. Trimester specific ranges for thyroid hormones in normal pregnancy. Thyroid Res Pract [serial online] 2016 [cited 2020 May 30 ];13:106-109
Available from: http://www.thetrp.net/article.asp?issn=0973-0354;year=2016;volume=13;issue=3;spage=106;epage=109;aulast=Mankar;type=0