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Year : 2012  |  Volume : 9  |  Issue : 1  |  Page : 7-8

Transplacental transfer of antithyroid antibodies a preliminary report

1 Department of Obstetrics and Gynecology, SUT Hospital, Trivandrum, Kerala, India
2 Department of General Medicine, SUT Hospital, Trivandrum, Kerala, India
3 Department of Neonatology, SUT Hospital, Trivandrum, Kerala, India

Correspondence Address:
Poulose K Poulose
Department of General Medicine, SUT Hospital, Trivandrum- 4, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-0354.92388

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Maternal hypothyroidism can affect the fetus in the antenatal period or later in life, but the role of maternal thyroid antibodies in hypothyroidism in the offspring is not well understood. Since thyroid autoantibodies can damage the thyroid gland, those with antibodies have a greater chance of developing thyroid dysfunction in future. The aim of the present prospective study was to estimate the occurrence of transplacental transfer of maternal antithyroid antibodies to the offspring and to study its immediate consequence to the offspring's thyroid function. TSH and antithyroid antibodies estimations of 20 offsprings of the hypothyroid and antithyroid-antibody-positive mothers were done. A high prevalence of either or both antithyroid antibodies (75%) was found in the offsprings of the antibody positive hypothyroid mothers though neonatal hypothyroidism was rare (5%). Only periodic follow-up of these children would reveal the importance of these antibodies in the neonatal period.

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