Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Home Print this page Email this page
Users Online: 318

Year : 2013  |  Volume : 10  |  Issue : 3  |  Page : 91-95

Thyroid status in Egyptian primary school children with iron deficiency anemia: Relationship to intellectual function

1 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt
2 Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt

Correspondence Address:
Kotb Abbass Metwalley
Pediatric Endocrinology Unit, Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-0354.116131

Rights and Permissions

Background: Only few studies concerning thyroid status and intellectual evaluation in iron deficiency anemia, which is frequently seen in primary school children in Egypt. Aim: The present study was planned to investigate the effect of iron deficiency anemia on the thyroid functions and intellectual activity of young children in a primary school. Settings and Design: Cross-sectional controlled study. Patients and Methods: This study was carried out on 60 primary school children aged 6-12 year with iron deficiency anemia (Group 1) and 20 children as control (Group 2). Complete blood count, iron, total iron binding capacityferritin, thyroid stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), free thyroid hormones (FT4 and FT3), and intelligence quotient (IQ) were determined in all the children included in the study. Results: TT3 and TT4 values were statistically lower while TSH is significantly higher in the study group as compared to control (P < 0.001 for each). Patients with hemoglobin (HB) level < 10 > 7 g/dl had significantly lower levels of serum FT3 and FT4 (P < 0.01 for both) and significantly higher levels of serum TSH (P < 0.05) as compared to patients with HB level <7 g/dl. Serum ferritin was correlated negatively with TSH levels (r = −0.76, P < 0.001) while positively with TT4 (r = 0.69, P < 0.001) and TT3 (r = 0.84, P < 0.001) levels. A significant positive correlation was found between serum level of TT3 and transferrin saturation% (r = 0.78, P < 0.001). Total, as well as performance IQ were significantly lower in patients than controls with P <0.05 for each. Significant positive correlations were observed between both total and performance IQ and thyroid hormone levels and iron status parameters. Conclusion: Egyptian primary school children with iron deficiency anemia especially severe type are liable to develop subclinical hypothyroidism and intellectual dysfunction. A randomized, double-blind, controlled study is needed to address the question of whether subclinical hypothyroidism associated with iron deficiency anemia should be treated with oral iron only or iron and levothyroxine combination aiming to prevent the combined effects of both conditions on cognitive function of the brain. Moreover, more comprehensive studies are needed to elucidate if the effect of iron deficiency anemia on thyroid status is reversible or not.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded493    
    Comments [Add]    
    Cited by others 8    

Recommend this journal