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Year : 2018  |  Volume : 15  |  Issue : 2  |  Page : 96-98

Fluctuating thyroid function in an infant born to mother with Graves' disease: To treat or not to treat

Department of Endocrinology, IPGMER, Kolkata, West Bengal, India

Correspondence Address:
Subhodip Pramanik
257, F. G Street, Telinipara, Bhadreswar, Hooghly - 712 125, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/trp.trp_8_18

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Graves' disease (GD) in pregnancy is common, and management is often challenging during pregnancy and postpartum. Antithyroid drugs (ATDs) cross the placenta and inhibit fetal thyroid hormone production, whereas anti-thyrotropin receptor antibody (TRAb) cross the placenta and stimulate thyroid hormone production and last longer than ATDs in neonate's circulation (3–12 weeks vs. 7–10 days). The resultant clinical presentation, therefore, depends on the age of the child and the balance between the opposing effect of ATD and TRAb. We present a case of an infant born to a mother with active GD, on ATD treatment who presented with diagnostic and therapeutic dilemma. We performed masterly inactivity as his thyrotropin levels sequentially changed from elevated at birth to suppressed at 1 month age to stable after 3 months onward. Knowledge of natural history and pathogenesis of alteration of thyroid function test in an infant born to mothers of GD on carbimazole are essential for appropriate management.

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