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Prevalence of hypothyroidism and thyroid autoimmunity in polycystic ovarian syndrome patients: A North Indian study
Diksha Goyal1, Pooja Relia2, Angela Sehra3, Deepak Khandelwal4, Deep Dutta5, Dimpy Jain6, Sanjay Kalra7
1 Department of Family Medicine, Maharaja Agrasen Hospital, Delhi, India
2 Department of Medicine, Maharaja Agrasen Hospital, Delhi, India
3 Department of Obstetrics and Gynecology, Maharaja Agrasen Hospital, Delhi, India
4 Department of Endocrinology, Maharaja Agrasen Hospital, Delhi, India
5 Department of Endocrinology, Venkateshwar Hospitals, Dwarka, New Delhi, India
6 Department of Dietetics, Maharaja Agrasen Hospital, Delhi, India
7 Department of Endocrinology, Bharti Hospital and Bharti Research Institute of Diabetes and Endocrinology, Karnal, Haryana, India
Correspondence Address:
Dr. Deepak Khandelwal
Department of Endocrinology, Maharaja Agrasen Hospital, Punjabi Bagh, Delhi - 110 026
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/trp.trp_7_19
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Background: There is limited data regarding the prevalence of hypothyroidism and thyroid autoimmunity in patients with polycystic ovarian syndrome (PCOS).
Objective: To evaluate thyroid status and frequency of hypothyroidism and thyroid autoimmunity in patients with PCOS in comparison to age-matched controls.
Materials and Methods: In a case–control study conducted at Gynecology outpatients department of our institute, 70 consecutive PCOS women diagnosed by Rotterdam criteria as well as 70 age-matched controls were evaluated. All patients underwent history, physical examination, thyroid function tests, and anti-thyroid peroxidase antibody (TPO Ab) tests. All patients who had positive TPO Ab also underwent ultrasonography of thyroid.
Results: Mean serum thyroid-stimulating hormone (TSH) in PCOS was significantly higher (5.11 ± 4.41 uU/ml vs. 3.62 ± 3.38 uU/ml; P = 0.026) than age-matched controls. Subclinical hypothyroidism (14.3% vs. 7.1%) and TPO Ab positivity (25.7% vs. 17.1%) were numerically higher in PCOS patients as compared to age-matched controls, although not statistically significant.
Conclusions: Mean serum TSH was significantly higher in PCOS patients as compared to age-matched controls. Numerically higher percentage of patients with PCOS had subclinical hypothyroidism and TPO Ab positivity; however, these were not statistically significant.
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