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ORIGINAL ARTICLE
Year : 2020  |  Volume : 17  |  Issue : 3  |  Page : 141-145

Pattern of Vitamin D deficiency in Hashimoto's thyroiditis and its association with thyroid hormone


1 Department of Medicine, MARKS Medical College and Hospital, Dhaka, Bangladesh
2 Department of Surgical Oncology, Delta Hospital Limited, Dhaka, Bangladesh

Correspondence Address:
Dr. Nazma Akter
Department of Medicine, MARKS Medical College and Hospital, Dhaka
Bangladesh
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/trp.trp_65_20

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Objective: The role of Vitamin D as an immune modulator has been recently emphasized. However, at this time, the research on its role in autoimmune thyroid disease is not conclusive. The purpose of this study was to examine the association of Hashimoto's thyroiditis (HT) and Vitamin D deficiency and to clarify the correlation between Vitamin D levels with thyroid hormone in patients with HT. Methodology: In this cross-sectional study, hypothyroid HT patients were selected among referents to the endocrinology outpatient clinic of MARKS Medical College and Hospital, Dhaka, Bangladesh, for thyroid evaluation from January 2019 to March 2020. A total of 150 patients were enrolled and placed in the newly diagnosed hypothyroid HT “case group,” and a “control group” included 145 apparently healthy individuals (matched for age and gender). All the patients underwent thyroid function tests and serum 25-hydroxyvitamin D (25(OH)D) levels. The antibodies of interest were thyroid peroxidase antibody and thyroglobulin antibody, suggesting HT cases. Data were analyzed using SPSS version 18 statistical software. Results: In this study, Vitamin D deficiency was prevalent in 32.2% of the “HT group” and 1.0% of the “control group” (P < 0.001). The Vitamin D-deficient participants had a significantly higher thyroid-stimulating hormone (TSH) and lower free thyroxine (FT4) level than the Vitamin D insufficient participants (TSH: 18.58 ± 8.73 vs. 8.52 ± 9.61 [μIU/mL], t = −7.816, P < 0.001; FT4: 0.81 ± 0.15 vs. 1.12 ± 0.17 [ng/dL], t = 13.36, P < 0.001, respectively). Concerning the HT case group, there was a significant negative correlation between serum 25(OH) Vitamin D and TSH (r = −0.178, P < 0.05). On the other hand, a significant positive correlation was recorded between serum 25(OH)D and serum FT4 levels (r = 0.610, P < 0.001). Conclusions: Patients with HT present with a reduced serum 25(OH)D level, and low serum Vitamin D levels were independently associated with high serum TSH levels and low serum FT4 levels in those with subnormal levels of Vitamin D. TSH is negatively correlated with 25(OH)D level. On the other hand, FT4 levels are positively correlated with 25(OH)D levels.


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