Year : 2014 | Volume
: 11 | Issue : 2 | Page : 81--82
Study of growth promoting effect of vitamin D supplementation in vitamin D deficient hypothyroid children
Santosh Kumar Singh
Endocrinologist, 301, Udaiman Apartment, Opp. A. N. College, Boring Road, Boring Road, Patna, Bihar, India
Santosh Kumar Singh
Endocrinologist, 301, Udaiman Apartment, Opp. A. N. College, Boring Road, Patna - 800 001, Bihar
Insulin-like growth factor 1 (IGF-1) regulates growth. 1,250HD 3((1,25 dihydroxy vitamin D3) promotes IGF-1 action, hence vitamin D deficiency may impair growth. This retrospective study showed that vitamin D supplementation in vitamin D deficient children promoted growth.
|How to cite this article:|
Singh SK. Study of growth promoting effect of vitamin D supplementation in vitamin D deficient hypothyroid children.Thyroid Res Pract 2014;11:81-82
|How to cite this URL:|
Singh SK. Study of growth promoting effect of vitamin D supplementation in vitamin D deficient hypothyroid children. Thyroid Res Pract [serial online] 2014 [cited 2022 Jan 28 ];11:81-82
Available from: https://www.thetrp.net/text.asp?2014/11/2/81/129737
1,250 Dihydroxy VitaminD3 1,250HD 3 has been shown to promote the action of insulin-like growth factor 1 (IGF-1) by increasing IGF-1 receptors. IGF-1 elevates 1,250HD 3 by stimulating 1α-hydroxylase and inhibits the catabolism of 1250HD 3 by decreasing 24-hydroxylase gene expression. Moreover, insulin-like growth factor-binding protein-3 (IGFBP-3) increases in response to 1250HD 3 . IGF-1 appears to have predominant role in regulation of growth. ,, This retrospective study was done to evaluate the growth promoting effect of vitamin D supplementation in vitamin D deficient hypothyroid children.
A retrospective study was done in five hypothyroid boys in the age range of 10-16 years. They were euthyroid when vitamin D supplementation was commenced. Supplementation was done with cholecalciferol 60,000 IU weekly for 8 weeks and then monthly. One patient received injectable vitamin D. Vitamin D deficiency was defined as 250HD 3 <20 ng/ml.
A 15.75-year-old boy showed a height gain of 4.3 cm in 1 year before commencement of vitamin D supplementation. He gained 3.5 cm in 6 months (7 cm/year) after vitamin D supplementation. His pre- and post-treatment 250HD 3 levels were 13.24 ng/mL and 21.57 ng/mL, respectively.
A 13.25-year-old boy showed a height gain of 5 cm in 9 months (6.67 cm/year) after vitamin D supplementation. His pre-treatment 250HD 3 level was 9.27 ng/mL.
A 15.5-year-old boy showed a height gain of 5 cm in 9 months (6.67 cm/year). His pre-treatment-SMR (Sexual Maturation Rate) was G 4 P 3 . His pre- and post-treatment 250HD 3 levels were 7.81 ng/mL and 44.47 ng/mL, respectively. He received injectable (IM-Intramuscular) vitamin D (3 lakh units every 3 month).
A 10-year-old boy showed a height gain of 1 cm in 2 months (6 cm/year) before vitamin D supplementation. He gained 4 cm in 6 months (8 cm/year) after vitamin supplementation. His pre- and post-treatment 250HD 3 levels were 4.5 ng/mL and 24.4 ng/mL, respectively.
A 12-year-old boy gained 0.5 cm in 2 months (3 cm/year) before vitamin D supplementation. With supplementation he gained 3 cm in 4 months (9 cm/year). His pre-treatment 250HD 3 level was 10.23 ng/mL.
There was a distinct gain in height with vitamin D supplementation in a boy (case A) who showed lesser height gain despite onset of puberty, prior to vitamin D supplementation. Similarly, there was greater height gain after vitamin D supplementation as compared to pre-supplementation (cases D and E).
Vitamin D supplementation showed a definite growth promoting effect which could be due to promotion of IGF-1 action and increment of IGFBP-3 by active vitamin D. Both IGF-1 and IGF-1/IGFBP-3 treatment has been shown to improve linear growth but, equimolar dose of IGF-1 is superior to IGF-1/IGFBP-3 treatment. 
The study highlights the importance of vitamin D supplementation in vitamin D deficient hypothyroid children for proper growth as impairment of growth could be due to hypothyroidism and concomitant vitamin D deficiency.
|1||Gómez JM. The role of insulin-like growth factor I components in the regulation of vitamin D. Curr Pharm Biotechnol 2006;7:125-32.|
|2||Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med 1997;336:633-40.|
|3||Ekström K, Carlsson-Skwirut C, Ritzén EM, Bang P. Insulin-like growth factor-I and insulin-like growth factor binding protein-3 cotreatment versus insulin-like growth factor-I alone in two brothers with growth hormone insensitivity syndrome: Effects on insulin sensitivity, body composition and linear growth. Horm Res Paediatr 2011;76:355-66.|