Year : 2017 | Volume
: 14 | Issue : 2 | Page : 63--70
Prevalence of hypothyroidism in Assam: A clinic-based observational study
Anindita Mahanta1, Sushmita Choudhury2, Sarojini Dutta Choudhury3
1 Department of Physiology, Gauhati Medical College, Guwahati, Assam, India
2 Department of Pulmonary Medicine, Tezpur Medical College, Tezpur, Assam, India
3 (Retd.) Department of Endocrinology, Gauhati Medical College, Guwahati, Assam, India
Introduction: Hypothyroidism is a common functional disorder of the thyroid gland. Despite extensive research, data on this subject are lacking from the northeastern part of India, which falls in the Sub-Himalayan goitrogenic belt. Therefore, we decided to study the profile of hypothyroidism in Assam, a northeastern state with the following objectives: to determine the prevalence of hypothyroidism and to describe the various modes of clinical presentation.
Materials and Methods: The study was conducted at a clinic-cum-radioimmunoassay laboratory in Guwahati, Assam, from January to November 2011. Two thousand and four hundred fifty-six patients referred to our center from different parts of Assam were evaluated clinically and their thyroid profile was estimated. Antithyroid peroxidase (TPO) antibody was estimated in 1950 patients.
Results: The prevalence of overt hypothyroidism was 10.9% (n = 267) and that of subclinical hypothyroidism was 13.1% (n = 321). Male:female ratio was 1:3. Among the cases of overt hypothyroidism, 247 (92.51%) were adult hypothyroids, 15 (5.62%) juvenile hypothyroids, and 5 (1.87%) cretins. The common presenting features of hypothyroidism were weakness (98%), lethargy (95%), dry and coarse skin (87%), and body ache (85%). Uncommon modes of presentation were pleural and pericardial effusion, low body weight, frequent motions, and palpitations. Postthyroidectomy and drug-induced hypothyroidism accounted for 2.38% cases each and postpartum hypothyroidism for 3.74% cases. Thirteen percent cases presented with goiter. The prevalence of anti-TPO antibody in the study population was 8.41%.
Conclusion: Hypothyroidsm is no longer a rarity, and Assam is no exception to this phenomenon. A population-based epidemiological study of thyroid disorders in Northeast India is an urgent need.
Department of Physiology, Gauhati Medical College, Guwahati - 781 032, Assam
|How to cite this article:|
Mahanta A, Choudhury S, Choudhury SD. Prevalence of hypothyroidism in Assam: A clinic-based observational study.Thyroid Res Pract 2017;14:63-70
|How to cite this URL:|
Mahanta A, Choudhury S, Choudhury SD. Prevalence of hypothyroidism in Assam: A clinic-based observational study. Thyroid Res Pract [serial online] 2017 [cited 2021 Jan 26 ];14:63-70
Available from: https://www.thetrp.net/article.asp?issn=0973-0354;year=2017;volume=14;issue=2;spage=63;epage=70;aulast=Mahanta;type=0