Thyroid Research and Practice

LETTER TO THE EDITOR
Year
: 2019  |  Volume : 16  |  Issue : 3  |  Page : 144-

Cord blood thyroid-stimulating hormone as a screening tool for congenital hypothyroidism: A single-center 5-year experience


Mahmood Dhahir Al-Mendalawi 
 Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Correspondence Address:
Prof. Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, P.O. Box 55302, Baghdad Post Office, Baghdad
Iraq




How to cite this article:
Al-Mendalawi MD. Cord blood thyroid-stimulating hormone as a screening tool for congenital hypothyroidism: A single-center 5-year experience.Thyroid Res Pract 2019;16:144-144


How to cite this URL:
Al-Mendalawi MD. Cord blood thyroid-stimulating hormone as a screening tool for congenital hypothyroidism: A single-center 5-year experience. Thyroid Res Pract [serial online] 2019 [cited 2022 Aug 13 ];16:144-144
Available from: https://www.thetrp.net/text.asp?2019/16/3/144/271155


Full Text



Sir,

It is worthy to comment on the interesting study by Bhatia and Rajwaniya published in the May–August 2019 issue of Thyroid Research and Practice.[1] The authors constructed normative values of cord blood thyroid-stimulating hormone (CBTSH) in a cohort of the Indian neonates and found that a cutoff CBTSH value >20 IU/ml could be used as a screening tool for congenital hypothyroidism (CH).[1] The authors mentioned that the main limitation of their study was that despite being a 5 years' project, the sample size was relatively small as the number of deliveries was less due to it being a private college.[1] I assume that the following methodological limitation is additionally contributing in casting suspicions on the study results. It is explicit that among many determinants, ethnicity has been noticed to be a significant determinant in the formulation of reference values of thyroid hormones.[2],[3] It has been suggested that ethnicity could impose differences in thyroid physiology, and hence, ethnic diversity within populations ought to be considered when constructing and interpreting screening thyroid-stimulating hormone cutoffs.[3] To my knowledge, India is a multiethnic country. The authors did not address the exact ethnic standards of the studied cohort. In spite of study limitations, the reported reference ranges for the CBTSH[1] could help in early detection of neonatal CH and ultimately, guiding proper therapy.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Bhatia R, Rajwaniya D. Cord blood thyroid-stimulating hormone as a screening tool for congenital hypothyroidism: A single-center 5-year experience. Thyroid Res Pract 2019;16:76-9.
2Önsesveren I, Barjaktarovic M, Chaker L, de Rijke YB, Jaddoe VW, van Santen HM, et al. Childhood thyroid function reference ranges and determinants: A literature overview and a prospective cohort study. Thyroid 2017;27:1360-9.
3Peters C, Brooke I, Heales S, Ifederu A, Langham S, Hindmarsh P, et al. Defining the newborn blood spot screening reference interval for TSH: Impact of ethnicity. J Clin Endocrinol Metab 2016;101:3445-9.