Thyroid Research and Practice

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 17  |  Issue : 2  |  Page : 76--81

Prevalence of thyroid dysfunction and thyroid autoimmunity in polycystic ovary syndrome: A multicenter study from Bangladesh


A. B. M. Kamrul-Hasan1, Fatema Tuz Zahura Aalpona2, Marufa Mustari3, Farhana Akter4, Palash Kumar Chanda1, Mohammad Motiur Rahman5, Mohammad Imtiaj Mahbub6, Shahjada Selim3 
1 Department of Endocrinology, Mymensingh Medical College, Mymensingh, Bangladesh
2 Department of Gyne and Obs, Mymensingh Medical College Hospital, Mymensingh, Bangladesh
3 Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
4 Department of Endocrinology, Chittagong Medical College, Chittagong, Bangladesh
5 Department of Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh
6 Department of Endocrinology, Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh

Correspondence Address:
Dr. A. B. M. Kamrul-Hasan
Department of Endocrinology, Mymensingh Medical College, Mymensingh-2200
Bangladesh

Background: Women with polycystic ovary syndrome (PCOS) have increased risks of thyroid dysfunction and thyroid autoimmunity. Data are limited regarding the prevalence of thyroid dysfunction and thyroid autoimmunity in patients with PCOS. Objective: The objective of this study was to evaluate thyroid function and thyroid autoimmunity in patients with PCOS. Materials and Methods: In this cross-sectional study, 500 women newly-diagnosed with PCOS attending the endocrinology outpatient departments of several tertiary hospitals of Bangladesh were evaluated. Serum thyroid-stimulating hormone (TSH), free thyroxine, and anti-thyroid peroxidase (anti-TPO) were measured in all. Results: The prevalence of thyroid dysfunction was 17% (11% subclinical hypothyroidism, 5.2% overt hypothyroidism, 0.4% subclinical hyperthyroidism, and 0.4% overt hyperthyroidism). Patients with normal and abnormal thyroid function had similar mean age, body mass index, waist circumference, diastolic blood pressure (BP), fasting plasma glucose, plasma glucose 2 h after oral glucose tolerance test, serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total testosterone, and prolactin levels. The frequencies of menstrual irregularities, acne, a first-degree family member with thyroid dysfunction, acanthosis nigricans, biochemical hyperandrogenism, and hyperprolactinemia were also similar. The patients with thyroid dysfunction had lower modified Ferriman–Gallwey score and hirsutism frequency. More patients in the thyroid dysfunction group had a history of weight gain during the course of PCOS onset. Higher rates of subfertility and goiter were also observed in patients with thyroid dysfunction; systolic BP was higher in this group. More than one-fifth (20.6%) of the study participants were positive for the anti-TPO antibody. Conclusions: Thyroid dysfunction and thyroid autoimmunity in Bangladeshi PCOS patients are very common.


How to cite this article:
Kamrul-Hasan AB, Aalpona FT, Mustari M, Akter F, Chanda PK, Rahman MM, Mahbub MI, Selim S. Prevalence of thyroid dysfunction and thyroid autoimmunity in polycystic ovary syndrome: A multicenter study from Bangladesh.Thyroid Res Pract 2020;17:76-81


How to cite this URL:
Kamrul-Hasan AB, Aalpona FT, Mustari M, Akter F, Chanda PK, Rahman MM, Mahbub MI, Selim S. Prevalence of thyroid dysfunction and thyroid autoimmunity in polycystic ovary syndrome: A multicenter study from Bangladesh. Thyroid Res Pract [serial online] 2020 [cited 2021 Feb 26 ];17:76-81
Available from: https://www.thetrp.net/article.asp?issn=0973-0354;year=2020;volume=17;issue=2;spage=76;epage=81;aulast=Kamrul-Hasan;type=0