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| Dehydroepiandrosterone supplementation in hypothyroidism S Kalra, B Kalra, G Nanda September-December 2006, 3(3):71-75Dehydroepiandrosterone sulphate (DHEA-S) deficiency is a common but under diagnosed cause of asthenia. The aim of the study was to assess the frequency of DHEA-S deficiency in hypothyroidism, its clinical correlates, and the effect of DHEA supplementation in these patients.
consecutive well-controlled hypothyroid patients, complaining 'asthenia' for ii month were assessed for DHEA-S levels. Patients with low DHEA-S or with levels in the lower quartile of normal were supplemented with oral DHEA. Monthly follow-up was done to assess biochemical and clinical results, aiming for a DHEA-S level in the upper half of normal range.
out of 72 patients had DHEA-S deficiency. The average dose of DHEA required to correct DHEA-S levels at 6 months was 18.75 ± 6.30mg/day. 82.60% patients reported marked improvement while 8.69% felt fair improvement in their symptoms with DHEA supplementation. There was no change in thyroxine dose requirement. A significant number of patients felt improvement in Libido (62.50%) and erectile function (25.0%). 8.71% dropped out due to various side effects. To conclude, DHEA-S deficiency is an easily treatable cause of asthenia in hypothyroidism. |
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REVIEW ARTICLE |
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| Screening for neonatal hypothyroidism : A review AM Samuel September-December 2006, 3(3):76-88This is an in-depth article focusing on the controversies that surround the issue of neonatal screening for hypothyroidism |
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OTHERS |
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| Cretinism : A 25 - year follow up Ratan KR Kotokey September-December 2006, 3(3):89-91 Full text not available [PDF] |
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EDITORIAL |
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| What is the optimal thyroid hormone replacement and how far are we from individualising thyroid hormone therapy? P Saravanan September-December 2006, 3(3):67-70 Full text not available [PDF] |
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EDITORIALS |
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| Reply to letter by Dr. Kumaresan A Naveen, TK Sabeer, A Bhattacharyya September-December 2006, 3(3):94-94 Full text not available [PDF] |
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| Letter to Editor K Kumaresan September-December 2006, 3(3):93-93 Full text not available [PDF] |
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| Thyroid Watch MG Pillai September-December 2006, 3(3):92-92 Full text not available [PDF] |
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